Buffering raises the pH of local anesthetic closer to physiological, making your local anesthetic of choice better and more predictable.

Onset lets you buffer cartridges of local anesthetic at chairside immediately before delivering the injection, making buffering simple, convenient and predictable.

 Buffering Made Simple as 1,2,3.

1 Buffer

The Onset Mixing Pen is a high-precision dispensing device used to mix two solutions together. Once assembled, the Mixing Pen enables the precise transfer of fluid from the 3 mL cartridge of Sodium Bicarbonate into a standard 1.8 mL cartridge of local anesthetic, allowing the two solutions to be mixed.

2 Load

Once the cartridge of local anesthetic is buffered, remove it from the Mixing Pen by unlocking the Cartridge Connector and pulling the mixed cartridge of local anesthetic straight out. Immediately load the buffered cartridge of local anesthetic into your dental syringe

3 Inject

Using your syringe and your technique, administer the buffered cartridge of local anesthetic to your patient within one minute of buffering for best results.

Making your local anesthetic better and more predictable

• Local anesthetics are manufactured at a low (acidic) pH when they arrive at your practice. After injection, the body must raise the pH of the anesthetic towards physiologic (7.4) before the patient can achieve pulpal anesthesia. This process keeps you, your staff and your patient waiting while the body works to raise the pH towards physiologic.
• Onset instantly buffers the local anesthetic in the cartridge immediately before it is loaded into the syringe to administer the injection.  Buffering the local anesthetic outside the body before the injection takes time and the patient’s physiology out of the buffering process. This makes your local anesthetic better and more predictable.

• Using Onset, your local anesthetic injection can have the pH of normal saline, instead of lemon juice!
• The Onset Buffering System allows you to buffer 4 of the 5 major local anesthetics used in dentistry: articaine, lidocaine, prilocaine and mepivacaine.
• At Onpharma, we understand you want to use YOUR local anesthetic, YOUR syringe and YOUR technique. With Onset, you can!